We are seeking an outstanding PhD candidate to join Mechanics in Biology and Medicine laboratory (MecBioMed.com) as part of a multidisciplinary collaborative project between Dr Emad Moeendarbary at the Department of Mechanical Engineering (University College London, UCL) and Dr Fernando Calvo at the Division of Cancer Biology (Institute of Cancer Research, London).
Metastatic disease is the major clinical complication in most types of cancer and the cause of 90% of cancer-related deaths. Whilst the mechanisms regulating the initial steps of metastasis (local invasion and intravasation) are becoming clearer, we still lack understanding of how circulating cancer cells manage to extravasate (i.e. adhere to the capillaries at secondary sites and cross the tight endothelial barrier). In addition to genetic and chemical microenvironmental cues, the physical interactions of cancer cells with endothelial cells and underlying matrix, as well as their modulation by mechanical forces and stiffness are key regulating factors in extravasation and metastatic success.
The project aims at identifying the main physical and biological determinants that underlie extravasation of tumour cells. We will employ and further develop in vitro microfluidic models to generate physiologically compatible systems. These will be used to image the extravasation processes with high spatiotemporal resolution under static conditions and under flow induced sheer stress. In addition, we combine our model with new physical measurement techniques to monitor force generation and modulation of mechanical properties of cancer cells, endothelial cells and sub-endothelial matrix during transendothelial migration. These approaches will provide an in depth understanding of the bio-physical determinants of cancer cell extravasation and be an ideal platform to further characterise the process. By interrogating the system, we aim to generate mechanistic insights and to identify key cellular processes and modulators that will be further tested to determine their functional and biological significance.
Environment, Research and Training
You will be based at UCL which is one of the world’s top multidisciplinary universities, with an international reputation for the quality of its research and teaching. As part of this project you will be working with a large interdisciplinary network of researchers. The candidate will benefit from state-of-the-art biomedical engineering research trainings and combined supervision by world leading scientists in the fields of cell biomechanics and cancer biology. You will have the opportunity to spend few months in the lab of our close collaborators at Massachusetts Institute of Technology and/or University of Maryland.
Value of award
You will be offered generous CRUK stipend for 4 years (£21,000/ year tax free) and funds for attending national/international conferences to present your work.
Eligible applicants should first contact Dr. Emad Moeendarbary (firstname.lastname@example.org) enclosing a cover letter (including the names and contact details of two referees), one-page research statement and two pages CV.