Miodownik wins Royal Society Faraday Prize and Lecture
“Professor Miodownik represents the excellent calibre of public engagement that the Michael Faraday Prize aims to celebrate." Professor Russell Foster CBE FMedSci FRS.Read more
Dr Rebecca Shipley; Dr Ivan Wall
Osteoporosis causes 8.9 million fragile fractures a year worldwide, which often result in non-unions and require either autologous or allogeneic grafting. Complications associated with these procedures, such as morbidity of the donor site and rejection of the implant, drive bone tissue engineering. Protocols for dynamic, 3D cell cultures, able to produce viable and sufficiently large tissue constructs, are investigated. Mathematical modelling is a useful tool in this process, highlighting the balance of chemical (nutrients) and mechanical (shear force) factors in the cell culture environment. The title of the research project is “Optimizing Manufacture Conditions for Production of 3D Bone Tissue using a Combination of Mathematical Modelling and Experimentation”. Analytical and computational fluid dynamics approaches are to be used, alongside a mathematical model on the metabolism of osteoblasts and mesenchymal stem cells. These aim to inform on the optimal oxygen levels, flow of nutrients and shear stress stimulation required to produce viable bone tissue in sufficiently large quantities in vitro. Experimental verification will be performed for a fully predictive cell-type specific model.
Huge congratulations to Mark Miodowinik, Professor of Materials and Society, at UCL Mechanical Engineering who was unanimously awarded the 2014 Royal Society Winton Prize for…Read more