This module sets out to give the student a sound understanding in the direct engineering of all living cells and organisms (multicellular systems). This will include the understanding of all processing sciences associated with the engineering of living cells and organisms for the fabrication of tissues and microenvironments, which will have the potential as a front running strategy for tissue engineering and regenerative medicine.
The course consists of understanding all the advanced processing approaches in-depth from lithography-based to ink-jet technology leading to emerging technologies. All the physical science issues related to the processing sciences of active cells will be addressed including the advantages and disadvantages of each process elucidating the necessity for the unearthing of novel approaches. The next stage will allow the students to gain a good understanding of the associated biology during the formation of tissues and structures from a genetic, genomic to physiological level.
Firstly, it will endeavour to bring all the students who are from a wide background to one level of understanding with respect to all the associated engineering and biological sciences. In harnessing this one level of “hybrid” students in-depth understanding of the associated engineering sciences and biology will be taught further where all the associated scientific considerations will be understood for making either a fully functional multi-cellular tissue and/or organ.
|UCL Credits/ ECTS
||Dr Suwan Jayasinghe
Method of Instruction
There are two visiting lecturers (molecular and cellular biologists) who will address issues in basic biology to those intricacies when directly engineering tissues and/or organs. In addition to these physical and life sciences based lectures, the students will have a few invited lectures from tissue engineering and biological centres having excellence in regenerative medicine and genomics. The module will end with a live demonstration of two jet-based technologies that are competing “head to head” for forming active biological structures from living cells and/or organisms. The intention of this module is twofold.
The reading list comprises of a mixture of handouts (scientific journal publications) and text books; e.g.
- Specific articles from Nature and its sister journals, Science, Regenerative Medicine, Biomaterials etc.
- Molecular biology of the cell: by Alberts et al.
- Human Chromosomes by Miller and Therman.
- Principles of Tissue Engineering by Lanza et al.
- Fundamentals of Tissue Engineering and Regenerative Medicine by Meter et al.