About Dr Vardakis
I’m a Research Associate in Integrative Cerebral Dynamics working with Professor Y. Ventikos, Dean Chou and Dr. Liwei Guo at UCL. My main focus is developing a computational framework that will aid in the understanding of cerebral diseases arising from Dementia (such as Alzheimer’s Disease, Vascular Dementia and Normal Pressure Hydrocephalus). We work within the VPH-DARE@IT project, which aims to deliver the first patient-specific predictive models for early differential diagnosis of dementias and their evolution.
The foundations of the mathematical modelling that we work on lie in Multiple-Network Poroelastic Theory, adapted to patient specific cases and simulated through a combination of Computational Fluid Dynamics (currently aided by High Performance Computing) and the Finite Element Method. We are developing a modelling platform that can handle, in an anatomically accurate and patient specific manner, the transport and interplay of blood and cerebrospinal fluid with the parenchyma – the neuronal and astrocytic tissue that constitutes the functioning brain.