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UCL Mechanical Engineering
Faculty of Engineering Sciences


John Vardakis

  • Research Associate - VPH-DARE Project
  • UCL Mechanical Engineering

Contact Dr Vardakis

+44 (0) 203 108 9515
Personal/lab or group website:
Fluidics and Biocomplexity Group
LinkedIn Profile

About Dr Vardakis

I’m a Research Associate in Integrative Cerebral Dynamics working with Professor Y. Ventikos, Dean Chou and Dr. Liwei Guo at UCL. My main focus is developing a computational framework that will aid in the understanding of cerebral diseases arising from Dementia (such as Alzheimer’s Disease, Vascular Dementia and Normal Pressure Hydrocephalus). We work within the VPH-DARE@IT project, which aims to deliver the first patient-specific predictive models for early differential diagnosis of dementias and their evolution.

The foundations of the mathematical modelling that we work on lie in Multiple-Network Poroelastic Theory, adapted to patient specific cases and simulated through a combination of Computational Fluid Dynamics (currently aided by High Performance Computing) and the Finite Element Method. We are developing a modelling platform that can handle, in an anatomically accurate and patient specific manner, the transport and interplay of blood and cerebrospinal fluid with the parenchyma – the neuronal and astrocytic tissue that constitutes the functioning brain.

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