Human Organ Atlas Hub (HOAHub)
HOAHub aims to create a physical and virtual Hub which uses the disruptive Hierarchical Phase-Contrast Imaging (HiP-CT) technique to scan whole human organs with local cellular resolution, producing a “Human Organ Atlas (HOA) in Health, Ageing and Disease”.
1. Bridge clinical imaging (radiology, millimetre scale) to molecular modalities (nanometre scale), providing unprecedented insights into our bodies in health, ageing and disease, helping cure or mitigate diseases from neuro-degeneration to musculoskeletal disorders to cancer.
2. Bring together interdisciplinary groups to produce the novel experimental and computational technologies needed to analyse and interpret the scale-bridging data.
|3. Enable the clinical impact of synchrotron imaging to be realised, by transforming HiP-CT into an efficient tool (from autopsy to beamtime to quantification).
4. Advance biological, computational and medical fields.
5. Provide anatomical training resources and a new Gold Standard for validating CT, MRI and 3D histology, inspiring a new generation of techniques and real-world clinical insights.
HOAHub consists of 7 interdisciplinary working groups to further develop the HiP-CT technique, address biological and biomedical challenges and propogate the technique to a wider community via training.
Introduction to the HOAHub vision and why we use HiP-CT by Prof. Peter D. Lee (UCL)
Introduction to the HiP-CT by Dr. Claire L. Walsh (UCL)
This project has been made possible by funding from:
- The European Synchrotron Radiation Facility (ESRF) — funding proposal MD-1252/MD-1290.
- The Chan Zuckerberg Initiative, a donor-advised fund of the Silicon Valley Community Foundation.
- The German Registry of COVID-19 Autopsies (DeRegCOVID), supported by the German Federal Ministry of Health.
- The Royal Academy of Engineering, UK.
- The Medical Research Council, UK.
- The Wellcome Trust, UK.
- Canadian Institute For Advanced Research, Canada.